Nebulized Morphine in Chest Trauma Patients: A Prospective Study

University Hospital, Mahdia75 enrolled

Overview

This is a prospective study carried out from 2018 to 2020 including patients aged ≥ 18 years, admitted for isolated chest trauma. Each patient received a nebulization of 10 mg morphine. If Visual Analog Score (VAS) assessed after 10 minutes still\> 4, nebulization was repeated every 10 minutes until pain relief. At 30 minutes, VAS\> 4 means failure.

The aim of this study was to determine the predictive factors of nebulized morphine failure in patients with chest trauma and to establish a score based on these factors to guide the analgesic protocol. Methods: This is a prospective study carried out from 2018 to 2020 including patients aged ≥ 18 years, admitted for isolated chest trauma. Each patient received a nebulization of 10 mg morphine. If Visual Analog Score (VAS) assessed after 10 minutes still\> 4, nebulization was repeated every 10 minutes until pain relief. At 30 minutes, VAS\> 4 means failure.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Blunt Injury of Thorax

Interventions

Morphine (+)DRUG

We performed a first nebulization of 10 mg (1mL) of morphine diluted in 4 mL of normal saline using a nebulizer with an oxygen flow rate of 8 L / min. The quality of analgesia was assessed by VAS at rest and cough after 10 minutes. If ≤ 4, we concluded to a success. If VAS was still\> 4, a second nebulization was performed. After 20 minutes, if VAS still higher than 4 we performed a third nebulization. If pain level was ≤ 4, we concluded to a success. After 30 minutes, if VAS still\> 4, we concluded to a failure of morphine nebulization. The patients were divided into two groups: morphine (+) group: good response to morphine in nebulization morphine (-) group: failure of morphine in nebulization

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged 18 years and over * victims of isolated chest trauma, * admitted to the intensive care unit Exclusion Criteria: * not consen * pregnant woman * polytrauma * hemodynamic instability with systolic blood pressure less than 100 mmHg, * treated with morphine during transport or in the emergency room * need initial ventilatory support, bradypnea (respiratory rate less than 12 cycles per minute) * allergy to opiods * initial pain Visual Analog Scale (VAS) ≤ 4

Locations (1)

Mahdia Hospital

Mahdia, Tunisia

Outcomes

Primary Outcomes

analgesia evaluated with visual scale

morphine (+) group: good response to morphine in nebulization morphine (-) group: failure of morphine in nebulization

Time frame: 30 minuts

Data from ClinicalTrials.gov

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