The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE). The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
50
saliva is collected for DNA extraction
panoramic radiography
teleradiography
Clinique dentaire
Strasbourg, France
RECRUITINGNumber of teeth
number of teeth
Time frame: at inclusion (day 1)
Recording of dental caries
recording of dental caries by Decayed Missing Filled Teeth index (DMFT index)
Time frame: at inclusion (day 1)
Recording the location of dental caries
the number of teeth affected using the international classification index
Time frame: at inclusion (day 1)
Drugs intra uterine exposure
drugs during pregnancy
Time frame: at inclusion (day 1)
Nutritional deficiencies
nutritional deficiencies assessed by a questionnaire
Time frame: at inclusion (day 1)
Periodontium
assessment of the periodontium by Maynard and Wilson classification
Time frame: at inclusion (day 1)
Oral hygiene
assesment of oral hygiene by plaque index (Löe and Silness, 1963)
Time frame: at inclusion (day 1)
Gingival inflammation
assesment of gingival inflammation by gingival index (Löe and Silness, 1963)
Time frame: at inclusion (day 1)
Treatment needs
assessment of treatment needs using Community Periodontal Index of treatment Needs (CPITN)
Time frame: at inclusion (day 1)
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intraoral X-rays
CT scan of maxillary and mandible
Face shape
assesment of the face shape : round, square, oval
Time frame: at inclusion (day 1)
Symmetry of the face
symmetry of the face (yes/no)
Time frame: at inclusion (day 1)
Profile (shape)
assessment of the profile (shape)
Time frame: at inclusion (day 1)
Smile
morphology of the smile
Time frame: at inclusion (day 1)
Vertical dimension
assessment of the vertical dimension: anterior infraclusion or overbite (in %)
Time frame: at inclusion (day 1)
Transversal dimension
assessment of the transversal dimension: posterior transversal dimension (in mm)
Time frame: at inclusion (day 1)
Sagittal dimension
Assessment of the sagittal dimension by Angle's classification
Time frame: at inclusion (day 1)
Chewing
Assessment of chewing by Plana's Functional Masticatory Angles (PFMA)
Time frame: at inclusion (day 1)
Nasal breathing
Assessment of nasal breathing by the Rosenthal's test
Time frame: at inclusion (day 1)
Swallowing
Assessment of swallowing by lingual interposition
Time frame: at inclusion (day 1)
Mutations causing PFE
Time frame: at inclusion (day 1)
Type of treatment performed
(orthodontics, surgery, prothesis)
Time frame: at inclusion (day 1)