Driving is a set of complex tasks and requires use of multiple cognitive domains, including attention, planning, and memory. In laboratory studies, the main psychoactive component in cannabis, delta-9-tetrahydrocannabinol (THC), was shown to impair short-term memory, attention, reaction time, tracking, and coordination, resulting, for instance, in significantly more deviations from the lane and increased break latency. Surveys and epidemiological studies suggest that cannabis consumption is associated with increased risks of collision. The current study aims to evaluate individual driving behavior and performance on various neurocognitive tests and their correlated neural networks while under the influence of cannabis and while sober. The investigators will use the STISIM driving simulator, which is fully MRI compatible, to study brain activation, while participants are performing various driving maneuvers. The goals of the study are: 1. identify driving performance and patterns in brain activation associated with cannabis exposure and compare them to brain patterns of the same participants while sober; 2. compare participant's performance on cognitive tasks while under the influence of cannabis and sober; 3. look for correlations between concentration of cannabinoids in the participants' blood and their driving performance and performance on cognitive tasks; 4. correlate demographic variables and personal history (e.g. tolerance to drug) with performance and brain activation while driving under the influence of cannabis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
12
Participants will be assigned to consume one of the cannabis strains and will complete testing immediately after consumption.
University Health Network
Toronto, Ontario, Canada
Change in neural activation on fMRI during driving simulation
Neural activation, based on BOLD signal, while completing driving tasks under the influence of cannabis and sober.
Time frame: 30-60 min after cannabis intake vs sober
Performance on driving simulator
Number of errors while completing driving tasks (e.g. turning, driving straight, speed maintenance, missed stop signs, etc.) under the influence of cannabis and sober.
Time frame: 30-60 min after cannabis intake vs sober
Performance on cognitive tasks
Cognitive test battery to assess various driving-related cognitive functions: attention, working memory, visual-spatial processing, processing speed, etc.
Time frame: 60-90 min after cannabis intake vs sober
Blood plasma concentration levels of cannabinoids
Concentration levels of THC and CBD throughout the session duration
Time frame: 10 min and 60 min after cannabis intake
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.