Inflammatory Biomarkers of Pediatric Pulmonary Hypertension

The Hospital for Sick Children74 enrolled

Overview

To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypertension, Pulmonary

Interventions

Blood testOTHER

Blood test

Eligibility

Sex: ALLMin age: 1 DayMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: -patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart. Exclusion Criteria: * active systemic infection * current active cancer * active cancer treatment * prior bone marrow transplant * prior solid organ transplant

Locations (1)

Hospital for Sick Children

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Measurement of HGMB1

Time frame: 1 day

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.