Eating With Eosinophilic Esophagitis (EoE)

Mayo Clinic31 enrolled

Overview

Is there a difference in the eating process for patients with active Eosinophilic Esophagitis (EoE) and those with inactive disease?

Eosinophilic esophagitis (EoE) patients develop adapted eating behaviors to prevent symptoms. These patients tend to cut their food small, chew extensively, take copious liquids with meals, and avoid foods that cause symptoms. No studies to date have directly evaluated these eating behaviors in patients with EoE with observation. Furthermore, none of the investigators' current metrics for patient symptom assessment visually evaluate the eating process nor are they compared before and after treatment. As a result, it is unclear if a patient's subjective perception of their eating difficulties and improvement matches with objective measures.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Eosinophilic Esophagitis (EoE)

Interventions

Observed eating sessionBEHAVIORAL

Eating a Jimmy Johns turkey or vegetarian sandwich

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age and older * Patients suspected to have Eosinophilic Esophagitis * Patients being treated for EoE with PPI or a steriod * EoE patients that are in remission by having less than 22 on the EEsAI questionnaire * Controls, patients that do not have EoE or other swallowing issues Exclusion Criteria: * Clinical evidence of infectious process potentially contributing to dysphagia (candidiasis, CMV,herpes) * Other cause of dysphagia identified at endoscopy (reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm) * EoE patients that do not eat sandwiches or feel they could not eat a sandwich.

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Observed eating session

number of bites of patient's with EoE and controls eating a Jimmy John's sandwich

Time frame: 15-90 minutes

Secondary Outcomes

Food slowness during eating session

number of bites that felt stuck among patients with EoE and controls when eating a Jimmy John's sandwich

Time frame: 15-90 minutes

Water during eating session

amount of water drank of patients with EoE and controls eating a Jimmy John's sandiwch

Time frame: 15-90 minutes

Eosinophilic Esophagitis activity Index (EEsAI) questionnaire

The EEsAI Pro uses the VDQ is visual dysphagia question AMS is avoidance, modification, slow eating question . These two along with questions on frequency of, duration of, pain associated with dysphagia make up the PRO (patient reported outcomes). The PRO is a number (0-100) calculated from the answer to the questions. A PRO \< 20 defines asymptomatic EoE.

Time frame: 10-15 minutes

Eosinophilic Esophagitis Quality of Life questionnaire

Higher score denote better quality of life. 0-4 as follows 4=not at all, 3=Slightly 2=moderately, 1=Quite a bit, 0= Extremely

Time frame: 10-15 minutes

Data from ClinicalTrials.gov

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