Safety and Pharmacokinetics of an Extract of Naringenin

Inclusion Criteria: * Adult (≥18 years) * Body mass index between 20 and 35 kg/m2 * Must have fasting blood sugar \<126 mg/dL) * Must be willing to refrain from consuming citrus fruits and tomato in any form, for 36 hours prior to each test day. Exclusion Criteria: * Report citrus allergies. * Report a history of cardiovascular disease, diabetes, or cancer * Have evidence of hepatic disease or dysfunction * Are currently pregnant or breastfeeding * Are women of childbearing potential who will not use an effective method of birth control * Chronically use of medications except over the counter medications that have been stopped 72 hours prior to the study visit * Report clinically significant GI malabsorption syndromes * Have clinically significant abnormal laboratory markers * Anticipate surgery during the study period. * Report history of substance abuse or alcoholism or significant psychiatric disorder that would interfere with the ability to complete the study. * Have donated blood during the month prior to study entry or plan to do so during the study. * Have participated in other studies using an investigational drug during the preceding three months. * Are current smokers or have smoked within the previous three months.