The purpose of this current prospective study is to determine the role of vitamin D in the development and restoration of spinal deformities in adolescence.
The investigator will record the medical history of each patient and information such as age, body size (weight, height) and body mass index (BMI = kg / m \^ 2). Girls will also be given the time of appearance of menstruation, a factor that needs to be evaluated because the growth of the skeleton continues three years after its appearance. Patients will be subjected to Adam's Test, x-ray's and as well as lateral bending radiographs.In the first contact with each patient, will be evaluated bone density measured by DEXA as well as haematological testing including PTH, alkaline phosphatase (ALP), calcium (Ca), phosphorus( P ), Calcitonin and, of course, vitamin D (total and metabolite 25 (OH) D). Each patient's follow-up will be completed in two years by a clinical examination every six months and a clinical, laboratory and radiological examination per year. Patients will be divided into two groups. In a group with patients with normal 25 (OH) D and in a second group with patients with low levels of 25 (OH) D. Members of the second group will receive substitution treatment with an appropriate formulation. The results will be collected and evaluated using statistical programme.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Alphacalcidol 0,5mg tablet
Papanikolaou General Hospital
Asvestochóri, Greece
RECRUITINGDepartment of Physical Medicine and Rehabilitation, University Hospital of Ioannina
Ioannina, Greece
RECRUITING25(OH)D
Measurement of the major metabolite of vitamin D
Time frame: 48 weeks
X - rays
Cobb angle measurement
Time frame: 48 weeks
Dexa
BMD and Z - score measurement
Time frame: 48 weeks
BMD (weight in kilograms, height in meters)
weight and height will be combined to report BMI in kg/m\^2
Time frame: 48 weeks
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