Clarithromycin (CLA)、amoxicillin (AMO)、metronidazole (MET)、levofloxacin (LEV) and tetracycline (TET) are commonly used antibiotics for Helicobacter pylori (Hp) therapy. However, the efficacy of treatment for Helicobacter pylori infection has decreased due to increasing resistance to CLA, MET and LEV. Studies had reported that beside antibiotics resistance, other factors such as age, sex, underlying disease, etc. may also affect the treatment efficacy. In some cases, when the MIC values were beyond the breakpoint, H. pylori strains with lower MIC value had better eradication than the ones with higher MIC value. However, few study investigated the relationship between MIC values and treatment outcome. The investigators aimed to analyze the impact of influencing factors, especially minimal inhibitory concentration (MIC) value, on the efficacy of different treatment regimens.
Study Type
OBSERVATIONAL
Enrollment
1,821
Triple or quadruple therapy consist of Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole.
Tzu-Chi Lai
Taipei, No.33, Linsen S. Rd., Zhongzheng Dist, Taiwan
RECRUITINGRelationship between eradication rate (%) of therapy regimen and influencing factors (eg. sex, age, diagnosis, MIC).
Time frame: 4 weeks after treatment finished.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.