The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
Study Type
OBSERVATIONAL
Enrollment
400
computed tomography, magnetic resosnance imaging, ultrasound
University Hospital Bonn
Bonn, Germany
RECRUITINGUniversity of Frankfurt
Frankfurt, Germany
RECRUITINGSapienza University of Rome
Roma, Italy
RECRUITINGSurvival time
time of survival
Time frame: up to 60 months
Time to clinical acute decompensations
time to occurrence of acute decompensations of liver cirrhosis (readmissions, hepatic encephalopathy, bleeding, ascites, hepatorenal syndrome, infections)
Time frame: up to 60 months
Time to clinical acute-on-chronic liver failure
acute-on-chronic liver failure according to EASL-CLIF-C definition (grade 1 (best) to 3 (worst)
Time frame: up to 60 months
Development of sarcopenia
Assessment of sarcopenia according to EASL-guideline
Time frame: up to 60 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.