Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension

Medical University of Graz10 enrolled

Overview

Insulin resistance is a key mechanism in metabolic disorders, which has also been implicated in the development of pulmonary hypertension. In this pilot study, the investigators´ goal is to directly determine insulin sensitivity in idiopathic pulmonary arterial hypertension patients and to compare the results with data from healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Insulin Resistance

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * signed informed consent form * patients with idiopathic or hereditary pulmonary hypertension / healthy controls Exclusion Criteria: * premenopausal women * other relevant lung disease * relevant left heart disease * untreated systemic hypertension * Diabetes mellitus * pulmonary hypertension other than idiopathic or hereditary form

Locations (1)

Medical University Graz, Division of Pulmonology

Graz, Styria, Austria

Outcomes

Primary Outcomes

Insulin resistance

Determination of insulin sensitivity using hyperinsulinemic-euglycemic clamp technique

Time frame: 1 day

Data from ClinicalTrials.gov

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