Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage

Assiut University144 enrolled

Overview

Termination of pregnancy is an important subject that has complex and emotional controversies. The most common time of termination of pregnancy is the mid-trimester which has two-thirds of all serious abortion-related complications. There are many indications for mid trimester termination of pregnancy such as missed abortion, serious fetal abnormalities and lastly some women do not wish to continue a pregnancy and will often request termination of pregnancy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

144

Conditions

Missed Abortion

Interventions

Misoprostol 100Mcg TabDRUG

women will receive misoprostol 100 mcg (Misotac, Sigma Pharmaceuticals, Egypt) vaginally applied every 6 hours till cervical dilatation.

Evening Primrose Oil 1000 MGDRUG

women will receive 4 capsules evening primrose oil 1000 mg (Primrose plus, Ema Pharm, Egypt) vaginally applied every 6 hours till cervical dilatation.

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Nullipara or previous vaginal delivery only * Bishop score was ≤ 5 * Women who will accept to participate in the study Exclusion Criteria: * Multiple gestations * Rupture of fetal membranes * Previous cesarean sections * Women with heavy bleeding * Evidence of low implanted placenta by US * Evidence of intra-uterine infection (either clinical or laboratory)

Locations (1)

Assiut Faculty of Medicine

Asyut, Egypt

Outcomes

Primary Outcomes

The induction to fetal expulsion time.

Duration of delivery of fetus

Time frame: 24 hours

Data from ClinicalTrials.gov

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