Vancomycin in the Target Site Treatment of Intracranial Infection

Xijing Hospital2 enrolled

Overview

Vancomycin, a novel intravenously administered antibiotic, currently plays a key role in the management of complicated multi-organism infections. However,current LC-MS/MS methods briefly describe parameters and the only reported internal standard was sometimes difficult to obtain. In our study,an updated LC-MS/MS method for the quantitative analysis of vancomycin in human serum was developed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Vancomycin

Interventions

VancomycinDRUG

Vancomycin, a novel intravenously administered glycylcycline antibiotic, currently plays a key role in the management of complicated multi-organism infections.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: In ICU; ventricle drainage was carried out; renal function is normal, namely creatinine clearance rate is \>60ml/min; Exclusion Criteria: women in pregnancy or lactation;in patients with renal insufficiency, the creatinine clearance rate (Clcr) is less than 60ml/min.

Outcomes

Primary Outcomes

Vancomycin concentration change in serum and cerebrospinal fluid

Quantitative analysis of vancomycin in serum and cerebrospinal fluid after treatment by an updated LC-MS/MS method.

Time frame: 0.5h, 1h, 1.5h, 3h, 5h, 7h, 9h, and 12h after treatment

Data from ClinicalTrials.gov

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