Effect of Norgestrel 75 mcg on Cervical Mucus and Ovarian Activity During Perfect Use, After One Delayed Intake and After a Missed Pill

Inclusion Criteria: * Women in good overall health with no chronic medical conditions that result in periodic exacerbations that require significant medical care * Women between 18 and 35 years inclusive at the screening visit * BMI\< 32 kg/m² * Regular menstrual cycles between 21 and 35 days when not using hormonal contraception. * Subjects postpartum or post-abortal must have one normal menstrual cycle (2 menses) prior to enrollment. * Subjects previously using Intra-Uterine Device (IUD) or taking hormonal contraception (or any other hormonal treatment, except an injectable treatment) need to have at least one menstrual cycle (2 menses) without the treatment before screening. * Subject previously using an injectable (DMPA), must have had their last injection at least 9 months before screening. * Women not at risk of pregnancy: not sexually active, or willing to protect all acts of intercourse with condoms, or have a sterile partner or have undergone previous tubal ligation (including validated Essure), or be in a same sex relationship. * Women able to give informed consent form to participate in the study and in the opinion of the investigator able to follow all study requirements, use the study medication and record the requested information appropriately * Intact uterus and both ovaries * At least one progesterone concentration \> 3 ng/mL (\>10 nmol/L) during the luteal phase of the screening period Exclusion Criteria: * Pregnant as confirmed by positive high-sensitivity urine pregnancy test at enrollment visit * Trying to conceive or desire to conceive in the next 3 months * Currently breastfeeding, or within the last 2 months * Known Polycystic Ovarian Syndrome (PCOS) * Cancer (or past history of any carcinoma or sarcoma) * Known abnormal thyroid status, if in clinical judgment of the investigator it cannot be controlled during the study * Known hypersensitivity to the ingredients of the test active substances or its excipients * Current acute liver disease and/or benign liver tumors * Have vaginal or cervical infection including clinical evidence of bacterial vaginosis * Evidence of abnormal cervical lesion * History of excisional or ablative treatment procedure on cervix (ie. Loop Electrosurgical Excision Procedure (LEEP), Cryotherapy, Cold Knife Cone) * Undiagnosed abnormal uterine bleeding * Prior malabsorptive-type bariatric surgery * Known or suspected alcoholism or illicit drug abuse * Use of any hormonal contraception or IUD other than the study medication during the study (including ulipristal acetate for emergency contraception in the past 5 days) * Use of any medications that can interfere with the metabolism of progestin-based contraceptives (e.g CYP3A4 enzymes inducers or inhibitors, etc) * Unstable diabetes mellitus * Current participation in any other trial of an investigational medicine or participation in the past two months (or within 5 elimination half-lives for chemical entities or 2 elimination half-lives for antibodies, whichever is the longer) before screening * Abnormalities in laboratory results or TVUS performed at screening visit recognized as clinically significant by the investigator * Conditions not suitable for frequent TVUS examinations, (e.g. virgo intacta) * In custody or submitted to an institution due to a judicial order * Relative or household member of the investigator's or sponsor's staff