Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and pre-posttreated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on healthy volunteers.
The purpose of this research project is to investigate the importance of blood vessel (vasodilatation), vessel wall inflammation and blood flow in arteries of headaches triggered by PACAP38 and for headache treated with sumatriptan (migraine medicine) and ketorolac (NSAID). In addition, we will investigate headache-related changes in the brain's network connectivity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
34
Receive intravenous infusion of sumatriptan
Receive intravenous infusion of ketorolac
Danish Headache Center
Glostrup Municipality, Denmark
Intra-extra cerebral arteries vasodilatation
PACAP38 vasodilatation reverse by sumatriptan but not ketorolac. A single-slab 3D time-of-flight (3D TOF) MRA of extra- and intracranial arteries will be acquired as described in previous studies (Amin et al., 2013, 2014). MRA data will be analyzed by LKEB-MRA vessel wall analysis software program. We will measure the circumference of vessels in millimeter in 4 predefined time points (0, 20, 60 and 110 min)
Time frame: 120 minutes
Headache score
Visual analog Scale
Time frame: 6 hours
Blood pressure
vital parameters recorded at hospital phase
Time frame: 2 hours
Headache characteristics
Standard headache questionnaire will be used to record headache localization, nausea, photo and phonophobia.
Time frame: 24 hours
Heart rate
vital parameters recorded at hospital phase
Time frame: 2 hours
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