Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2

University Hospital, Caen400 enrolled

Overview

Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective cognitive disorders; (ii) healthy control subjects. The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

400

Conditions

Cerebrovascular Disorders Brain Lesion Degenerative Disease Developmental Disability

Interventions

Neuropsychological testingBEHAVIORAL

Experimental test about cognitive deficit of interest and standard neuropsychological tests

Brain ImagingOTHER

Anatomical, diffusion, and/or functional MRI

Galvanic Vestibular Stimulation (GVS)OTHER

Stimulation versus Sham

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 17 years * French language * Effective contraception for women during the study * Informed consent * No alcohol intake the day before the exam * For patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology, developmental or degenerative disease with cognitive deficit Exclusion Criteria: * For healthy volunteers: previous neurological history (except non complicated migraine or epilepsy), previous psychiatric history (except depression with good evolution or anxiety), or severe cranial traumatism * For patients: vigilance disorders, severe depression or anxiety. * For both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI or GVS if applicable, participation in another trial or former involvement in another trial within one month.

Outcomes

Primary Outcomes

Cognitive Deficit

The cognitive deficit of interest will depend on the localization of the brain lesion. The outcome measure could be a standardized neuropsychological test or an experimental test specifically elaborated for this protocol.

Time frame: 3 months to more than 2 years