This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
Inpatient management of acute decompensated heart failure centers around the efficient relief of congestion with IV diuretics and vasoactive agents. For the majority of patients, non-invasive, clinical bedside tools such as jugular venous pressure, pulmonary auscultation and daily weights are used to estimate cardiac filling pressures and guide diuresis. However, these methods are subject to significant inter-observer variability and can be unreliable for various reasons. Furthermore, recent studies have shown that overt signs of clinical congestion correlate poorly with hemodynamic congestion assessed by invasive means. Remote Dielectric Sensing is a novel technology that enables the non-invasive assessment of lung fluid content using a wearable vest. ReDS measurements have been shown to correlate with fluid status in hospitalized HF patients and have been used to remotely monitor ambulatory HF patients for signs of pre-clinical hemodynamic congestion. In this prospective, randomized study, we will assess the utility of ReDS guided diuresis in hospitalized patients with acute decompensated heart failure. All patients will receive daily ReDS measurements, but only treating physicians in the intervention group will be able to use these values to guide treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
ReDS measurements will be shared with the treating clinicians who can use the information to guide diuresis and determine the appropriate timing of discharge
ReDS measurements will not be shared with the treating clinicians, who will guide diuresis using standard clinical criteria
University of California, San Francisco
San Francisco, California, United States
RECRUITINGNet Fluid Balance during hospitalization
Cumulative net fluid balance assessed by In's and Out's recorded in the Electronic Medical Record (EMR) during hospitalization
Time frame: During hospitalization, approximately 7 days
Change in GFR from admission to discharge
Net change in GFR (calculated using the Chronic Kidney Disease Epidemiology 2009 equation) from admission to discharge
Time frame: During hospitalization, approximately 7 days
Length of Stay in hospital
Duration of hospitalization
Time frame: During hospitalization, approximately 7 days
Major adverse cardiac events at 30 days
The combined rate of cardiovascular mortality or heart failure readmission at 30 days
Time frame: 30 Days after discharge
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