Peg-Interferon Alpha 2b Combined With Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074 (BEAT-2)

Inclusion Criteria: * HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or by HIV-1 antigen, plasma HIV-1 RNA VL * Ability and willingness of participant to provide informed consent * Men and women aged ≥18 years * Clinically stable on their first or second ART regimen that includes a boosted protease inhibitor or an integrase inhibitor. The current regimen should be stable for 4 weeks at the time of entry. Changes while the patient HIV viral load is undetectable does not count toward the number of ART regimens used, (for example an individual switching from an NNRTI-based regimen to an integrase inhibitor based regimen while the HIV viral load is undetectable will still be in their first regimen) * HIV-1 RNA that is \<50 copies/mL using a FDA-approved assay performed by any laboratory that has a CLIA certification or its equivalent within 56 days prior to study entry NOTE: HIV-1 RNA must be measured at least once in the 24 weeks prior to entry and at least 3 days before the screening measure. Single determinations that are between ≥50 and \<400 copies/mL (i.e., blips) are allowed as long as the preceding and subsequent determinations are \<50 copies/mL. The screening value may serve as the subsequent determination \<50 copies/mL following a blip * Screening CD4+ T-cell count ≥450 cells/μL within 45 days prior to study entry * Willingness to have blood samples collected and used for study-related research purposes * The following laboratory values obtained within 45 days prior to enrollment: * Absolute neutrophil count (ANC) ≥1000 cells/mm3 * Hemoglobin ≥12.0 g/dL for men and ≥11 g/dL for women * Platelet count 100,000/mm3 * Creatinine clearance ≥60 mL/min estimated by the Cockcroft-Gault equation * Alanine aminotransferase (ALT) ≤2.5 x ULN * Pancreatic amylase ≤ 1.5 ULN and lipase ≤ 1.5 ULN and triglycerides ≤ 750 mg/dl * total bilirubin ≤ 1.5x ULN, (if not receiving atazanavir) OR direct bilirubin ≤ 1 mg/dl (if receiving atazanavir) * For females of reproductive potential (i.e., women who have not been post-menopausal for at least 24 consecutive months, who have had menses within the preceding 24 months, or women who have not undergone surgical sterilization, specifically hysterectomy and/or bilateral oophorectomy or bilateral salpingectomy), negative urine pregnancy test (with a sensitivity of 15-25 mIU/mL) within 48 hours prior to screening and entry. ADDITIONAL REQUIREMENTS BIOLOGICAL FEMALES ARE NOTED IN CLINICAL PROTOCOL. -Female partners of reproductive potential of male study participants on study drug would be educated that: At least two of the following contraceptives MUST be used appropriately by female partners of reproductive potential of male study participants and/or their male partners with one method being highly effective and the other method being either highly effective or less effective as listed below: Highly Effective Methods of Contraception * Male condoms with spermicide * Hormone-based contraceptives including combined oral contraceptive pills, vaginal ring, injectables, implants, and intrauterine devices (IUDs) such as Mirena by male participant's female partner of reproductive potential. * Nonhormonal IUDs, such as ParaGard * Tubal ligation * Complete Abstinence\* * \*Complete abstinence as defined as complete avoidance of heterosexual intercourse. Participants who choose complete abstinence are not required to use a second method of contraception. Acceptable alternate methods of highly effective contraception must be discussed in the event that the participant chooses to forego complete abstinence. NOTE: Female partners of male participants participating in the study may use hormone based contraceptives as one of the acceptable methods of contraception since they will not be receiving study drug. * Negative HBsAg result obtained within 6 months prior to study entry. * HCV antibody negative result within 6 months prior to entry, or if the HCV antibody result is positive, a negative HCV RNA obtained within 6 months prior to study entry. Treated and cured HCV infected participants are allowed. * Adequate venous access in at least one arm * Body weight ≥ 125 and ≤ 300 lbs * A non-clinically significant electrocardiogram (EKG, see section 7.2) for: 1. men \>45 years or women \> 55 years of age 2. younger subjects of either sex with two risk factors for coronary artery disease \[smoking, hypertension (BP \>140/90 or on antihypertensive medications), low HDL (\<40 mg/dl), family history of premature CHD (\<55 yrs males/\<65 females 3. subjects with a Framingham score \> 15% (men) or 10% (women) Exclusion Criteria: * Susceptibility to bNAb 10-1074 based on IC90 greater than 2.0 µg/mL or susceptibility to bNAb 3BNC117 based on IC90 greater than 1.5 µg/mL using the Monogram Phenosense Assay on sample obtained on ART in absence of a subsequent documentation of a HIV viral load of greater than 1,000 copies on a collection date after that of the bNAb sensitivity sample. * Previous receipt of humanized or human monoclonal antibody whether licensed or investigational * Weight \>300 lbs or \<125 lbs * History of an AIDS-defining illness * Ongoing AIDS-related opportunistic infection (including oral thrush) * History of a severe allergic reaction with generalized urticaria, angioedema, or anaphylaxis in the 2 years prior to enrollment * Currently pregnant, breastfeeding, or planning pregnancy * Receipt of other investigational study agent within 30 days prior to enrollment * Current or prior medications: * Confirmed clinical history of developing resistance to ART regimens that resulted in treatment changes * Receiving didanosine as part of the participant's ART regimen at the time of screening * Ongoing treatment with Isoniazid, Pyrazinamide, Rifabutin, Rifampicin, Ganciclovir, Valgancyclovir, Oxymetholone, Thalidomide or Theophylline. * Ongoing treatment with anticoagulants * Use of any investigational drug within 30 days prior to screening * History or current use of immunomodulatory therapy for over 2 weeks during the 6 months prior to enrollment, including, but not limited to: * IFN-α or γ (recombinant or pegylated) * Systemic corticosteroids (inhaled steroids allowed at the discretion of the Investigator) * Systemic cancer chemotherapy/irradiation * cyclosporin; tacrolimus (FK-506) * OKT-3 * Any Interleukin, including IL-2 * Cyclophosphamide * Methotrexate * IVIG (gamma globulin) * G/M-CSF * Hydroxyurea * Thalidomide * Pentoxifylline * Thymopentin, thymosin * Dithiocarbonate * Polyribonucleoside. * History of adverse or allergic reactions to any type-1 interferon (e.g. IFN-α2a, IFN-α2b, IFN-β) * Any other chronic or clinically significant medical condition that in the opinion of investigator would jeopardize the safety or rights of the volunteer, including, clinically significant forms of: * Drug or alcohol abuse * Severe asthma * Uncontrolled hypertension * Type I diabetes mellitus, or type II diabetes mellitus that is not controlled with oral agents and/or insulin (i.e.: subjects with a history of diabetes mellitus and HA1C of \> 9 in the last 3 months or at screening) * Psychiatric disorders, including severe depression and/or suicidal ideation * Heart disease * Cancer or hematologic malignancies * Prior diagnosis of multiple sclerosis or other neurodegenerative disorders * Liver cirrhosis or hepatic decompensation * Chronic HCV infection (HCV viremia), or HBV Ag positive and/ or HBV viremia (Notice: subjects with prior HCV infection with a documented sustained virologic response at 24 weeks post treatment prior to screening are eligible for enrollment. * Major organ transplantation with an existing functional graft * Active autoimmune diseases, including autoimmune hepatitis * History of retinopathy or clinically significant ophthalmologic disease * Opportunistic infections or other active infectious diseases * Other conditions, such as active drug/alcohol abuse or dependence, that in the opinion of the Investigator would interfere with study compliance. * Initiation of treatment during acute infection