Allogeneic Bone Marrow MSC Therapy for Knee Osteoarthritis

Inclusion Criteria: 1. Male or female at least 40 years old, completing the informed consent process for participating the clinical trial 2. Patients diagnosed with unilateral/bilateral knee osteoarthritis of grade II, III and IV (Kellgren and Lawrence scale) as assessed by doctors, who are not suitable for, or not willing to undergo knee surgery (including total knee replacement) 3. Pain of the knee as assessed by visual analogue scale (VAS) to be 4 or higher (VAS ≥ 4) 4. Body mass index (BMI) between 20 and 35 kg/m2 5. Neither local/systemic bacteremia nor acute infection around the knee joint Exclusion Criteria: 1. Physiologically or psychologically inappropriate for participating the trial as evaluated by the investigators 2. Patients with congenital or acquired bone hypoplasia (Varus more than 10o or Valgus more than 20o) 3. BMI less than 20 or more than 35 (Class II obesity) 4. Female who is pregnant or breastfeeding, or in childbearing age; male or female subjects who are not able to use appropriate contraception methods during the trial 5. Patients with muscular or neurological diseases causing deformity of the targeted knee joint(s), which might interfere with the evaluation of trial. 6. Patients with malignant tumors, or benign tumors that may interfere with the trial treatment or subsequent evaluation. 7. Immunocompromised or patients suffering from immune diseases under long-term immuno-suppressive medication such as steroids, however, topical steroid is not included 8. Patients with coagulation or hematological disorders not suitable for intra-articular (IA) injection 9. Known or possible allergy to components in the product under trial 10. Patients had any IA injection or surgery of the targeted knee within the last 3 months 11. Patients with crippled lower limbs rated ACR functional class IV (Largely or Wholly Incapacitated) or cannot walk without one/two arms-operated walking assisting device (defined by CNS15390) 12. Spontaneous knee osteonecrosis 13. Previous surgery of the knee that may cause metal imaging artifacts on imaging study 14. Patients have claustrophobia and/or cannot take magnetic resonance imaging (MRI) test 15. Any metal devices placed in the body such as pacemaker, artificial heart valve, or hemostatic clamps/clips for intracranial aneurysm posing risk under magnetic field (of MRI) 16. Patients with severe unilateral (or bilateral) knee osteoarthritis who have decided to receive surgery (including total knee replacement) on the affected knee (or both knees if bilateral) after advised by their surgeon. 17. Having participated other clinical trials with medications (including cellular therapy) within the past 3 months prior to subject screening