An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury

N/AActive Not RecruitingNCT03590028

University of Chicago180 enrolled

Overview

This is a single center randomized trial that seeks to determine if the use of an automated real-time electronic medical record Acute Kidney Injury (AKI) risk score can improve patient outcomes through the use of an early standardized nephrology focused intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

180

Conditions

Acute Kidney Injury

Interventions

Early Nephrology Consult (ENC)OTHER

The electronic risk prediction algorithm (ESTOP-AKI) will interface with electronic medical data to determine the likelihood for the patient to develop AKI. Early Nephrology Consult (ENC) will be implemented. A nephrologist will assess the subject and consult with their care team to advise a treatment plan during the hospitalization.

Standard of Care (SOC)OTHER

Subjects will receive nephrology consultation at the typical timepoint after symptoms of AKI appear.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age \>18 years old 2. Initial ESTOP AKI score ≥0.01 within the last 8 hours. Exclusion Criteria: 1. Voluntary refusal or missing written consent of the patient / legal representative. 2. Patients with a known history of end-stage renal disease on dialysis (including renal transplantation). 3. Patients without a measured serum creatinine value during their inpatient stay. 4. Patients with a creatinine \>4.0 mg/dl at the time of admission or available in the electronic health record (EHR) from the last 6 months. 5. Patients with prior episode of Kidney Disease Improving Global Outcomes (KDIGO) defined AKI during this same hospitalization- regardless of ESTOP AKI score. 6. Patients with prior renal consultation during their admission.

Locations (1)

University of Chicago Medical Center

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Peak change in milligrams per deciliter (mg/dL) in serum creatinine (SCr) level over a 7-day interval

The primary endpoint of interest, change in serum creatinine (SCr), is the peak change from study entry in SCr level over a 7-day interval. The change in SCr is defined as the maximal change in creatinine over this interval, and aim to detect a clinical difference in change in SCr between the SOC and ENC treatment groups.

Time frame: 7-day interval

Data from ClinicalTrials.gov

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