The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation

Mansoura University115 enrolled

Overview

We try to assess the potential role of telomerase reverse transcriptase and MicroRNA (miR-155) in diagnosis of non-muscle-invasive bladder cancer and their correlation with stage and grade of the tumor.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

115

Conditions

Bladder Cancer Bladder Disease Bladder Neoplasm Micro-RNA

Interventions

MicroRNAs-155DIAGNOSTIC_TEST

Quantitative analysis of cell-free miR-155 using RT-qPCR.

Human telomerase reverse transcriptaseDIAGNOSTIC_TEST

Analysis TERT by TERT messenger RNA (mRNA)expression by reverse transcription-quantitative polymerase chain reaction.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women 18 years or older. * Patient with hematuria suspected to be of bladder origin clinically. * Willing to be participate in the study. Exclusion Criteria: * Patient having another malignancy. * Hematuria of other causes as trauma and stones

Locations (1)

Urology and Nephrology Center

Al Mansurah, Aldakahlia, Egypt

Outcomes

Primary Outcomes

sensitivity, specificity and positive and negative predictive values of combined MicroRNA-155 And Telomerase Reverse Transcriptase In diagnosis Of Non-Muscle Invasive Bladder Cancer

compared by standard final pathological specimen

Time frame: 1 year

Secondary Outcomes

correlation between serum Vit D and Non-Muscle Invasive Bladder Cancer

measured serum Vit D in ng/mL.

Time frame: 1 year

Data from ClinicalTrials.gov

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