Left Atrial Thrombus on Transesophageal Echocardiography

Medical University of Warsaw200 enrolled

Overview

The aim of the study is to assess the prevalence of left atrial thrombus in patients with atrial fibrillation (AF) or atrial flutter (AFI), in whom transesophageal echocardiography is performed before AF/AFl cardioversion or ablation.

Atrial fibrillation (AF) and atrial flutter (AFI) increase the risk of thromboembolic events by promoting clot formation in the left atrium (LA). Transesophageal echocardiography (TEE) is routinely used to exclude the presence of an LA thrombus before AF/AFI ablation or cardioversion. So far, it has not been established what is the optimal combination of noninvasive parameters for thromboembolic risk stratification in this setting. The present study is aimed to compare the prevalence of LA thrombus in patients on different anticoagulant regimens, identify predictors of LA thrombus and validate the newly developed CHA2DS2-VASc-AF-GFR score (and to compare its predictive value in LA thrombus identification with those of the CHA2DS2-VASc and the CHADS2 scores). The study protocol all patients with AF or AFl in whom TEE will be performed (to assess their eligibility for cardioversion or ablation), hospitalized in a participating center during study period.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Atrial Fibrillation Atrial Flutter Transesophageal Echocardiography Ablation Cardioversion Thrombus; Embolism

Interventions

Transesophageal echocardiographyDIAGNOSTIC_TEST

Transesophageal echocardiography will be used to exclude the presence of an LA thrombus before AF/AFI ablation or cardioversion.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with AF or AFl in whom TEE will be performed (to assess their eligibility for cardioversion or ablation), hospitalized in a participating center during study period.

Locations (1)

1st Department of Cariology of Medcial University of Warsaw

Warsaw, Masovian Voivodeship, Poland

RECRUITING

Outcomes

Primary Outcomes

Assessment of the prevalence of LA thrombus in patients with AF/AFI, in whom TEE is performed before AF/AFl cardioversion or ablation.

Time frame: One day

Secondary Outcomes

Comparison of the prevalence of LA thrombus in patients on different anticoagulant regimens.

Time frame: Up to 12 months

Identification of the predictors of LA thrombus.

Time frame: Up to 12 months

Validation of the the newly developed CHA2DS2-VASc-AF-GFR score (and to compare its predictive value in LA thrombus identification with those of the CHA2DS2-VASc and the CHADS2 scores).

Time frame: Up to 12 months

Data from ClinicalTrials.gov

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