This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.
Patients from 6 to 18 years old with asthma and receiving a treatment by salbutamol according to the usual care will be recruited. Saliva from patients will be collected using Oragen®.DNA OG-575 kit.
Study Type
OBSERVATIONAL
Enrollment
99
Measurement of bronchodilator response (BDR)
Hôpital Necker -Enfants Malades
Paris, France
pre- and post-bronchodilator VEMS value
comparison of acute response to salbutamol calculated as the percentage difference between the pre- and post-bronchodilator VEMS value (BDR = 100 x \[post-VEMS - pre-VEMS\]/pre-VEMS) according to the genotype of the rs1504982
Time frame: Day 0
Locating other regions of the PDE4 gene that may be associated with the response to salbutamol by gene mapping (using SNP tags)
To identify other SNPs on PDE4 associated with the response (BDR) to salbutamol in childhood asthma.
Time frame: Day 0
Screening other SNPs (other genes than PDE4) associated with the response to salbutamol in childhood asthma using SNP tags
To identify other genes that could be associated with the phenotype of interest (BDR) by tagging other genes.
Time frame: Day 0
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