Observational Study to Assess Optimal ECPR Settings After Resuscitation

Inclusion Criteria: * Witnessed cardiac arrest or signs of life during CPR (such as gasping or movement) * Age\>18 and \< 70 years * Duration of low-flow \< 60 min before decision to proceed with ECPR * High quality CPR (defined as end-tidal carbon dioxide (CO2et) \>10 mmHg) provided for a minimum of 15 minutes without return of spontaneous circulation (ROSC) * Presumed cardiac cause of cardiac arrest (such as Chest pain before collapse, ventricular tachycardia/ventricular fibrillation (VT/VF) as initial rhythm or ST-elevation on ECG) * Cerebral oxymetry monitoring initiated during CPR preceding ECPR Exclusion Criteria: * Patients with a GCS\<15 before CPR. * Known pre-arrest cerebral performance category CPC ≥ 3 * Presumed noncardiac cause * Unwitnessed collapse * Suspected or confirmed pregnancy * ROSC within 5 minutes of Advanced cardiopulmonary life support (ACLS) performed by emergency medical service (EMS) team * Conscious patient * Known bleeding diathesis or suspected or confirmed acute or recent intracranial bleeding * Suspected or confirmed acute stroke * Known severe chronic organ dysfunction or other limitations to therapy * "Do not resuscitate" order or other circumstances that make 180 day survival unlikely