A Study to Evaluate ACT-246475 Fate in Healthy Male Subjects

Main Inclusion Criteria: * Signed informed consent in the local language prior to any studymandated procedure, * Healthy male subjects aged between 45 and 65 years (inclusive) at screening, * No clinically significant findings on the physical examination at screening, * Body mass index of 18.0-28.0 kg/m2 (inclusive) at screening, * Systolic blood pressure (BP) 100-140 mmHg, diastolic BP 50-90 mmHg, and pulse rate 45-90 bpm (inclusive), measured on either arm, after 5 min in the supine position at screening, * 12-lead electrocardiogram (ECG) without clinically relevant abnormalities, measured after 5 min in the supine position at screening, * Values of closure time tested with the Platelet Function Analyzer equipment, for both cartridges of collagen/epinephrine and collagen/adenosine diphosphate below the upper limit of normal range at screening. Main Exclusion Criteria: * Known hypersensitivity to ACT-246475 or drugs of the same class, or any excipients of the ACT-246475 formulation, * History or clinical evidence of any disease and/or existence of any surgical or medical condition, which might interfere with the absorption, distribution, metabolism or excretion of the study treatment (appendectomy and herniotomy allowed, cholecystectomy not allowed), * Family or personal history of prolonged bleeding (e.g., after surgical intervention) or bleeding disorders (e.g., thrombocytopenia, clotting disturbances), intracranial vascular diseases, stroke, reasonable suspicion of vascular malformations, or peptic ulcers, * Platelet count \< 120 x10\^9 L-1 at screening, * Previous exposure to ACT-246475, * Participation in another study with a radiation burden of \> 0.1 mSv and ≤ 1.0 mSv in a period of 1 year prior to screening; a radiation burden of \> 1 mSv and ≤ 2.0 mSv in a period of 2 years prior to screening, etc. (add 1 year per 1 mSv), * Exposure to radiation for diagnostic reasons (except dental X-rays and plain X-rays of thorax and bony skeleton \[excluding spinal column\]), during work or during participation in a clinical study, in the period of 1 year prior to screening, * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol.