Safety and Immune Response of Increasing Doses of OVX836 After Intramuscular or Intranasal Administrations in Healthy Subjects

Inclusion Criteria: 1. Have given written informed consent approved by the relevant Ethical Committee governing the site. 2. Overtly healthy male or female subjects, as determined by medical history and medical examination. 3. Between the ages of 18 and 49 years, inclusive, on screening. 4. Between the Body Mass Index of 18 and 24 kg/m2, inclusive, on screening. 5. Clinical laboratory test results within normal reference range, or results with acceptable deviations that are judged to be Non Clinically Significant by the Investigator. 6. Blood Pressure and Heart Rate within normal reference range, or results with acceptable deviations that are judged to be Non Clinically Significant by the Investigator. 7. Are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures. Exclusion Criteria: 1. Previous Influenza vaccination within the 6 months before screening. 2. History of significant medical illness such as auto immune diseases, immune deficiency, uncontrolled diabetes or hypertension, heart or renal or hepatic diseases, as judged by the investigator. 3. For female subjects: pregnant or breast-feeding or of childbearing potential without appropriate contraceptive methods or with positive pregnancy test at screening. 4. Having received another vaccination within 3 months prior to screening. 5. Plan to receive other vaccine during the study period. 6. Administration of any investigational or non-registered drug or vaccine within 3 months prior to the first administration of study vaccine. 7. History of receiving blood or blood component or IgG within 3 months prior to screening. 8. Presence of acute febrile illness (temperature \> 38°C, temporary exclusion criteria). 9. For intranasal route: common cold and rhinitis (temporary exclusion criteria). 10. Individuals with any progressive or severe neurological disorder, seizure disorder or Guillain-Barré syndrome. 11. Individuals with behavioral or cognitive impairment or psychiatric disease that, in the opinion of the Investigator, may interfere with the subject's ability to participate in the study. 12. History of alcoholism and/or drug abuse or tabagism (above 10 cigarettes a day). 13. Treatment that can affect immune response such as systemic or high dose inhaled corticosteroids (\>800µg/day beclometasone or equivalent), radiation treatment, cytotoxic drugs or chronic non-steroidal anti-inflammatory drugs (more than 4 weeks), interferon, immunomodulators, allergy shots, as judged by the Investigator. 14. Positive test for HIV, HBV or HCV at screening. 15. History of severe allergic reactions and/or anaphylaxis or serious adverse reactions to vaccines and antibiotics. 16. Any contraindication to intranasal or intramuscular administration, as judged by the Investigator. 17. Individuals with history of any illness that, in the opinion of the Investigator, might interfere with the results of the study or pose additional risk to the subjects due to participation in the study. 18. Sponsor employees or Investigator site personnel directly affiliated with this study, and their immediate families. Immediate family is defined as a spouse, parent, child or sibling, whether biological or legally adopted.