Human Gut Microbiota and Prebiotic Response

Duke University41 enrolled

Overview

This study is designed to examine the shift in gut microbiota and their metabolism after consumption of a dietary supplement (prebiotic) by healthy participants. The investigators will provide participants with a panel of over the counter prebiotics and monitor their gut microbiome response in stool. All prebiotics will be commercially available, over-the-counter food, food additives, or dietary supplements, without any known market-use adverse effects beyond minimal discomfort.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy Gut Microbiota

Interventions

Prebiotic A - inulinDIETARY_SUPPLEMENT

Pre-weighed packages will be given twice daily for 5 days.

Prebiotic B - galactooligosaccharides(GOS)DIETARY_SUPPLEMENT

Pre-weighed packages will be given twice daily for 5 days.

Prebiotic C - wheat dextrinDIETARY_SUPPLEMENT

Pre-weighed packages will be given twice daily for 5 days.

Eligibility

Sex: ALLMin age: 17 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provide Stool Samples at no risk to yourself Exclusion Criteria: * No oral antibiotic treatments within previous 1 month * No known allergy to milk products or lactose intolerance * no known allergy to wheat or gluten intolerance * no history of irritable bowel syndrome * no history of inflammatory bowel disease * no history of type-2 diabetes * no history of chronic kidney disease or reduced kidney function * no current intestinal obstructions * no current untreated colorectal cancer * not currently pregnant or breastfeeding

Locations (1)

Duke University

Durham, North Carolina, United States

Outcomes

Primary Outcomes

change in levels of SCFAs in stool samples

Time frame: Baseline and 6 weeks

Secondary Outcomes

change in levels of cytokines in stool samples

Time frame: Baseline and 6 weeks

Data from ClinicalTrials.gov

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