National CounterACT Initiative

Patient Inclusion Criteria: 1. Males or females age greater or equal 2 years of age 2. Weight greater or equal to 10 kg 3. Parental/guardian permission (informed consent) and if appropriate, child assent. Patient Exclusion Criteria: 1. Known primary mitochondrial disorder. 2. Use of an investigational drug within 30 days prior to enrollment. 3. Parents/guardians or subjects who in the opinion of the Investigator, may be non-compliant with study schedules or procedures. Volunteer Inclusion Criteria 1. Males or females \> 18 years of age 2. Employee, trainee, or student informed consent Volunteer Exclusion Criteria: 1. Prior enrollment in this study. 2. Known primary mitochondrial disorder. 3. Use of an investigational drug within 30 days prior to enrollment.