The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery. 0.5 to 1.0 mL of undiluted vitreous was removed using the vitreous cutter positioned in the midvitreous cavity. Samples were immediately frozen and stored at -80°C until analysis. Sample analyses were performed using an high-performance liquid chromatography system. The lower limit of quantitation was 0.8 ng/mL. PGE2 levels were analyzed using the Prostaglandin E2 Monoclonal EIA Kit (Cayman Chemical Company) according to the manufacturer's instructions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
104
Artificial tears for 3 days preoperatively
Dosing of drug 3 days prior to surgery
Dosing of drug 3 days prior to surgery
Dosing of drug 3 days prior to surgery
Dosing of drug 3 days prior to surgery
Eye Clinic, Departement of Medical Surgical Sciences and Health, University of Trieste
Trieste, TS, Italy
Vitreous NSAIDs and PGE2 levels
Time frame: 3 days after topical NSAID administration
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.