There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly. The primary reason for this is fear of hypoglycaemia and loss of glycaemic control associated with exercise. This loss of glycaemic control is associated with traditional moderate intensity continous aerobic exercise advocated in the guidelines for exercise in people with type 1 diabetes. Recent work (unpublished) from our lab suggests high intensity interval training (HIT) may reduce the risk of hypoglycaemia in people with type 1 diabetes, however stronger evidence is needed before firm conclusions can be drawn. Therefore, the aim of this study is to determine the effects of HIT on glycaemic control in people with type 1 diabetes compared to no exercise and traditional moderate intensity continous exercise. 24 people with type 1 diabetes will be recruited to complete a randomised counterbalanced cross over study comparing 3x 2-week interventions periods. During these intervention periods participant will maintain their habitual lifestyle but complete either no exercise (control), traditional moderate intensity continous exercise or high intensity interval training. Throughout the intervention periods participants glycaemic control will be monitored using a flash glucose monitor.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
11
Participants will complete 6 sessions of high intensity interval training during a 2 week intervention period. The programme involves repeated 1 minute bouts of simple on the spot movements interspersed with 1 minute of rest.
Participants will complete 6 sessions of moderate intensity continous training during a 2 week intervention period. Participants will be asked to complete 30 minutes of continuous exercise.
Liverpool John Moores University
Liverpool, United Kingdom
Severe hypoglycaemia
Number of severe hypoglycaemic events (\<3mmol/l) during the 2 week intervention period
Time frame: 2 weeks
Mean glucose
mean glucose level over 2 week recording period
Time frame: 2 weeks
% of time in level 2 hypoglycaemia (<3.0mmol/L)
% of time in level 2 hypoglycaemia (\<3.0mmol/L) over 2 week recording period
Time frame: 2 weeks
% of time in level 1 hypoglycaemia (3.0-3.9mmol/L)
% of time in level 1 hypoglycaemia (3.0-3.9mmol/L) over 2 week recording period
Time frame: 2 weeks
% of time in target range (3.9-10.0mmol/L)
% of time in target range (3.9-10.0mmol/L) over 2 week recording period
Time frame: 2 weeks
% of time in level 1 hyperglycaemia (10.0-13.9mmol/L)
% of time in level 1 hyperglycaemia (10.0-13.9mmol/L) over 2 week recording period
Time frame: 2 weeks
% of time in level 2 hyperglycaemia (>13.9mmol/L)
% of time in level 2 hyperglycaemia (\>13.9mmol/L) over 2 week recording period
Time frame: 2 weeks
glycaemic variability (coefficient of variation and Standard Deviation)
glycaemic variability over 2 week recording period
Time frame: 2 weeks
area under the curve of episodes of hypoglycaemia and hyperglycaemia
area under the curve of episodes of hypoglycaemia and hyperglycaemia 2 week recording period
Time frame: 2 weeks
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