A Study to Evaluate AXR-159 Ophthalmic Solution in Patients With Dry Eye Disease

Inclusion Criteria: * Male or female, 18 years of age or older at screening visit * Best-corrected visual acuity (BCVA) of 20/100 or better (Snellen equivalent), using the logarithm of the minimum angle of resolution (LogMAR) in each eye * Reported history of dry eye for at least 6 months * Corneal fluorescein staining score ≥ 2 * Eye dryness score ≥ 40 * Total Ocular Surface Disease Index (OSDI) score \> 18 Exclusion Criteria: * Uncontrolled ocular disease (except for dry eye disease/keratoconjunctivitis sicca) or uncontrolled systemic disease * Patient has glaucoma, ocular hypertension, on IOP-lowering medications or have previously undergone any glaucoma laser or surgical procedure. * Corneal abnormality or disorder that impacts normal spreading of the tear film (keratoconus, pterygia, scarring) or compromised corneal integrity * BCVA worse than 20/100 in either eye * Current use of punctal plugs, anticipated insertion during the study, or a history of punctal cautery in either eye * Keratoconjunctivitis sicca secondary to destruction of conjunctival goblet cells * Patients with clinically significant inflammation of the lid margin such as anterior blepharitis or ocular rosacea * Recent (within the past 3 months) ocular surgery, trauma or herpes * Use of contact lenses in either eye within one month prior to the screening visit or anticipated use during the study