Vortioxetine add-on Treatment Improves the Symptoms in Patients With Bipolar Depression

Inclusion Criteria: * Patients diagnosed with Bipolar I Disorder, Bipolar II Disorder, Other Specified Bipolar and Related Disorder, Unspecified Bipolar and Related Disorder by Diagnostic and Statistical Manual (DSM)-V criteria. * 18 to 65 years of age * Patients with Montgomery-Åsberg Depression Rating Scale score ≥ 23 (moderate to severe depression), after 4 weeks or more of treatment by main medication of mood stabilizer or antipsychotics * Patients with Young Mania Rating Scale score lower than 10, after 4 weeks or more of treatment by main medication of mood stabilizer or antipsychotics Exclusion Criteria: * Currently experiencing manic, hypomanic, or mixed episode * Comorbid with serious medical illness * Comorbid with substance use disorder, medical illness or other neurologic disorder that may have caused depressive symptoms other than by bipolar disorder * Pregnancy or Breastfeeding women * Those who are hypersensitive to the main or other ingredient of the medication * Currently on Monoamine oxidase (MAO) inhibitor or those who have discontinued MAO inhibitor in the last 14 days * Severe liver disease, severe renal disease * Bleeding tendency/disorder