The principal means of measuring motor impairment in Huntington disease (HD) is the Unified Huntington's Disease Rating Scale (UHDRS) total motor score, which is subjective, categorical, requires significant training to administer correctly, and only captures impairments in clinic. In this Direct to Phase II SBIR we will develop a wearable sensor system for objective, sensitive, and continuous assessment of Huntington's chorea during activities of daily living. The developed technology could be used clinically to detect changes in motor function in response to medications, or could be used scientifically to expedite and reduce the cost of early stage pharmaceutical clinical trials.
Study Type
OBSERVATIONAL
Enrollment
50
Wearable sensor system for monitoring Huntington's chorea during activities of daily living
University of Rochester
Rochester, New York, United States
RECRUITINGChorea severity score
Remotely monitored chorea severity score based on movement data during activities of daily living
Time frame: 12 months
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