Based on the research background and the preliminary research basis of the research group, in order to answer the material basis and micro-physical environment change characteristics of knee osteoarthritis sensitization acupoints and provide scientific basis for in-depth study of sensitization of acupoints. This study plans to use knee osteoarthritis as a research vehicle, and use microdialysis combined with high performance liquid chromatography to analyze the local material basis and key indicators of common sensitization points in knee osteoarthritis.
This trial is a single-centre, normal controlled, parallel group, clinical trial. The trial is an explorative, pilot trial designed to reveal the change of the main material group in sensitized acupoints caused by knee osteoarthritis, and provide the key signal substance and its changing characteristics of knee osteoarthritis sensitized acupoints.
Study Type
OBSERVATIONAL
Enrollment
33
Use microdialysis skill to collect dialyzate at sensitization acupoints
Shuguang
Chengdu, Sichuan, China
Serotonin concentration
The serotonin concentration of KOA patients' sensitized acupoints was compared with that of the normal acupoints in healthy volunteers.
Time frame: 2018-7-12---2020-7-1
Histamine concentration
The histamine concentration of KOA patients' sensitized acupoints was compared with that of the normal acupoints in healthy volunteers.
Time frame: 2018-7-12---2020-7-1
Adenosine triphosphate concentration
The adenosine triphosphate concentration of KOA patients' sensitized acupoints was compared with that of the normal acupoints in healthy volunteers.
Time frame: 2018-7-12---2020-7-1
WOMAC score
The WOMAC score of KOA patients was compared with healthy volunteers.
Time frame: 2018-7-12---2020-7-1
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