Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on blood and tissue oxygenation (ABGA, NIRS).
Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). At rest and under exercise data from ABGA and NIRS will be compared at low altitude and High Altitude.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
28
Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland
Arterial blood oxygenation at High Altitude (2500m above sea level)
Difference in arterial blood oxygenation at Low Altitude (Zurich, 470m above sea level) and High Altitude (Säntis; 2500m above sea level)
Time frame: within 5 hours
Near infrared spectroscopy at High Altitude (2500m)
Difference in cerebral tissue oxygenation and muscle tissue oxygenation measured by near infrared spectroscopy at low Altitude (Zurich) and High Altitude (Säntis, 2500m)
Time frame: within 5 hours
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