Safety of LAIV4 in Children With Asthma

Inclusion Criteria: * Children between 5-11 years of age, inclusive, at enrollment * Participant must have a current diagnosis of persistent asthma (Physician diagnosis of asthma and current prescribed use of a long-acting controller medication. For purposes of this study, we have considered "controller" medications to be any single or combination use of long-acting medications used to prevent asthma exacerbations and to achieve long-term control of asthma (as compared to short-acting rescue medication).) * Parent(s) or legal guardian(s) must provide written, informed consent and participant must provide assent as appropriate for age prior to initiation of study procedures and according to local IRB requirements * Parent(s) or legal guardian(s) and participant must be willing and able to comply with planned study procedures and be available for all study visits * Is in good health, other than their asthma, as determined by medical history * English or Spanish literate (only English-speaking participants will be included at the Cincinnati and Duke sites) * Intention of being available for entire study period and complete all relevant study procedures, including follow-up using at least one of the following methods: phone calls, text messages, or emails Exclusion Criteria: * Acute illness and/or a reported oral temperature of ≥ 100.4°F within 72 hours prior to enrollment (this may result in a temporary delay of vaccination) * Use of antipyretic medication during the preceding 24 hours that might mask a fever (this may result in a temporary delay of vaccination) * History of a severe allergic reaction (e.g., anaphylaxis) after a previous dose of any influenza vaccine or after any component of the influenza vaccine, including egg protein. * Receipt of any licensed vaccine within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to vaccination or planned receipt of any licensed vaccine within 42 days after vaccination * Receipt of current year's (2018-2019 influenza season) licensed influenza vaccine for children 9-11 years (only). (Clarification: Children aged 5-8 years are permitted to be enrolled if they have received zero or one dose of the 2018-2019 influenza season vaccine, and require two doses of the 2018-2019 influenza vaccine.) * Received an investigational agent (licensed or unlicensed vaccine, drug, biologic, device, blood product, or medication) in the 28 days prior to enrollment or planned receipt before 42 days after vaccination * Have immunosuppression as a result of an underlying illness or treatment, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months * Have taken ≥20mg/day of prednisone or its equivalent, for 14 days or more within the past 28 days * Have known active neoplasm or a history of any hematologic malignancy * Has had a previous exacerbation of their asthma symptoms requiring systemic steroids within the prior 28 days, or has had a life-threatening exacerbation of asthma in the past two years (e.g. hypoxic seizure, mechanical ventilation) * Received influenza antiviral medication within 48 hours prior to study vaccination * History of Guillian-Barré syndrome within 6 weeks of previous influenza vaccination * Have any condition that, in the opinion of the investigator, would interfere with the evaluation of the responses or would place the participant at unacceptable risk of injury * Has a positive urine or serum pregnancy test within 24 hours prior to vaccination in a post-menarchal female. LAIV is not recommended for use in pregnant females. * Currently taking aspirin or aspirin-containing products * Any parent(s) or legal guardian(s) who is an immediate relative of study staff or is an employee supervised by study staff.