Preoperative Intraarterial Chemoembolization Combined With Radiotherpy in Locally Advanced Rectal Cancer

Inclusion Criteria: * Histologic or cytologic diagnosis of rectal cancer, Stage IV. * Males or females between 18 Years to 75 Years. * No prior cisplatin-based chemotherapy or radiotherapy. * Performance status of 0～2 on the ECOG criteria. * Adequate hematologic (Leukocyte count \>= 4,000/uL, neutrophil count \>= 1,500/uL, hemoglobin \>= 10 g/dL, platelets \>= 100,000/uL), hepatic (AST \& ALT =\< upper normal limit(UNL)x1.5, bilirubin level =\< UNLx1.5), and renal (creatinine =\< UNL x1.5 or creatinine clearance rate ≥60 ml/min) function. * Patient can take oral medicine * Patient compliance that allow adequate follow-up. Informed consent from patient or patient's relative. Exclusion Criteria: * Patient with allergic to S-1 or ingredient of Oxaliplatin * Patient with Peripheral neuropathy * Diagnosed fibrosis of lung;pulmonary fibrosis or interstitial pneumonia within 28 days. * Medically uncontrolled serious heart, renal failure, liver failure, hemorrhagic peptic ulcer, paralysis of intestine , ileus, poor controlled diabetes. * Enrollment in other study. * Pregnant or breast-feeding. * Seriously psyche or intelligence problem. * Inability to comply with protocol or study procedures.