Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma

Moroccan Society of Surgery84 enrolled

Overview

Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This retrospective multicentric study aimed to predict the prognosis of patients with complete pathological response after neoadjuvant treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Rectal Neoplasms

Interventions

rectal resectionPROCEDURE

total mesorectal excision

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria * patients with a histologically proven low rectal adenocarcinoma, * no previous or synchronous colorectal disease, * UICC stage I-III patients who underwent neoadjuvant chemoradiotherapy or chemotherapy, * followed by total mesorectal excision (TME), and * a complete pathological response defined as ypT0N0 Exclusion Criteria: \- all patients with metastatic tumors or missing data

Locations (8)

Batna anticancer center

Algiers, Algeria

Mohammed V University Medical School, Surgery Department, Military Hospital

Rabat, Please Enter the State Or Province, Morocco

Mohammed V University Medical School, Surgical Department "A", Ibn Sina Hospital

Rabat, Please Enter the State Or Province, Morocco

Outcomes

Primary Outcomes

Local recurrence rate

A postoperative local recurrence was defined by biopsy-proven or radiographic evidence of local recurrent disease.

Time frame: From date of surgery until the date of first documented local progression assessed up to 100 months

Distant recurrence rate

A postoperative distant recurrence was defined by biopsy-proven or radiographic evidence of distant recurrent disease.

Time frame: From date of surgery until the date of first documented distant progression assessed up to 100 months

Secondary Outcomes

Predictive factors of disease free survival

Disease free survival was defined as the period between the day of surgery and the date of recurrence or the last date of follow-up

Time frame: From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months

Data from ClinicalTrials.gov

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