Phase III Trial of Adjuvant Chemo-radiotherapy After D2 Surgery of Gastric Cancer

Inclusion Criteria: 1. Aged 18-75； 2. Had histologically confirmed adenocarcinoma of the stomach or gastroesophageal junction； 3. ECOG 0-1； 4. Subjects has to voluntarily join the study and sign the Informed Consent Form for the study; 5. D2 and R0 resection; 6. Locally advanced (UICC stage, T4, N2, N3) gastric cancer after surgery; 7. More than 15 lymph nodes; 8. Adequate organ function as defined below: Hematologic ANC ≥ 2\*109/L, Platelets ≥ 100\*109/L, AST and ALT ≤ 2.5×ULN, TBIL ≤ 1.5×ULN. Exclusion Criteria: 1. Previous radiotherapy or chemotherapy； 2. Inadequate organ function; 3. Pregnant or lactating women or women of childbearing potential.