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Estimating Usual Iodine Intake From Spot Urinary Iodine Concentrations

N/ACompletedNCT03602404
Swiss Federal Institute of Technology1,592 enrolled

Overview

The overall objective of this study is to develop a reliable method to obtain habitual iodine intakes from spot urinary iodine concentration (UIC) and to assess the prevalence of inadequate iodine intake in school-age children and women of reproductive age. We will evaluate different methods to estimate iodine intake from UIC and estimate the prevalence of inadequate and excess iodine intake in UIC studies conducted in populations with low, adequate and high iodine intakes using the the established estimated average requirement (EAR)/Tolerable Upper Intake Level (UL) cut-point method.

Study Type

OBSERVATIONAL

Enrollment

1,592

Conditions

Iodine Deficiency

Eligibility

Sex: ALLMin age: 9 YearsMax age: 13 YearsHealthy volunteers:
Medical Language ↔ Plain English
Inclusion Criteria: * lived in study area \>= 12 months * no reported intake of Amiodarone * no history of thyroid dysfunction / goiter (past \& present) * no exposure to iodine containing contrast agents within the last 12 months Second arm: Women aged 18 - 49, exclusion / inclusion criteria apply, plus non-pregnant, non-lactating.

Locations (2)

University of Papua New Guinea

Sia, Morobe Province, Papua New Guinea

Almazov Medical Research Center

Saint Petersburg, Russia

Outcomes

Primary Outcomes

Estimated iodine intake

Estimated daily iodine intake of the study population derived from urinary iodine and creatinine concentrations measured in spot urine samples

Time frame: 17 months

Secondary Outcomes

Urinary iodine concentration

Measured in spot urine samples and 24 h urine collections

Time frame: 17 months

Urinary creatinine concentration

Measured in spot urine samples and 24 h urine collections

Time frame: 17 months

Data from ClinicalTrials.gov

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