The aim is to investigate the safety and potential effect of Low-energy Shockwave Therapy (ESWT) on the transplanted kidney. The treatment consist of ESWT two times a week for three weeks, six treatments in total. The hypothesis is that ESWT with improve the renal function, by reducing proteinuria (in a 24-hour urine collection test) and improving renal clearance of 51Cr-EDTA. The safety of ESWT on the renal allograft will be assessed during and after treatments.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
2 treatments a week for 3 weeks consisting of 3000 focused shockwaves of 4Hz and 0,20mJ/mm2 applied over the kidney allograft. Treatment is performed using the STORZ DUOLITH® SD1 T-TOP "F-SW ultra"
Odense University Hospital
Odense, Region Syddanmark, Denmark
RECRUITINGChange in renal clearance (GFR)
Comparing GFR before and 3 months after treatment sessions
Time frame: At baseline and 3 months after treatment
Change in albumin/creatine ratio in 24hour urine sample
Comparing the results from a sample of 24-hour urine sample before, 1 month after and 3 months after treatment.
Time frame: At baseline, 1 month after treatment and 3 months after treatment
Incidens of treatment-related adverse events
The participants answer questions about side-effects before and after each treatment session, at 1 month followup and 3 month followup. After 1 month a ultrasound of the kidney will show if there is any bleeding in the graft-tissue after the 6 treatments.
Time frame: up to 4 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.