Safety of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells in Subjects With Osteoarthritis

Inclusion Criteria: * Male or female volunteers between 35-65 years. * X-ray evidence of osteoarthritis (grade II-III in Kellgren-Lawrence). * Chronic joint pain (\>5 visual analogue scale) in knee. * BMI ≤ 29. * Voluntary acceptance and signature of informed consent. * Willing to attend study visits and lab sample recollection. * Lab values within normal reference values. * Willing to use effective birth control methods. Exclusion Criteria: * Inflammatory arthritis. * Generalized infection. * Active cancer or history of cancer in the past 5 years. * Receiving oral or intraarticular steroids. * Positive labs for HIV, Hepatitis B or C. * Recent trauma in the target joint. * Debris in joint. * Subjects that have undergone or need to undergo arthroscopic knee surgery in the target joint. * History of joint substitution, intraarticular fractures, osteotomy, arthroplasty or menisectomy. * Clinically significant knee misalignment. * Other illnesses that the investigator considers clinically significant. * Participating in another clinical trial three months before enrolling. * Women that are pregnant, lactating or result positive in the pregnancy test during screening. * Known allergies to bovine products. * Subjects taking anticoagulants.