Nutrition, Body Composition, and Sleep

University of Arkansas, Fayetteville45 enrolled

Overview

The purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Sleep Body Composition Strength Insulin Sensitivity Energy Expenditure

Interventions

Whey proteinDIETARY_SUPPLEMENT

Participants in the protein arms will receive whey protein daily for 16 weeks.

Omega-3 fatty acidsDIETARY_SUPPLEMENT

Participants in the omega-3 fatty acid arms will receive capsules daily for 16 weeks.

Eligibility

Sex: FEMALEMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Postmenopausal women (12+ months following last reported menstrual cycle) Exclusion Criteria: * food allergies * diet restrictions * do not habitually eat breakfast * picky eaters\\regularly consume protein or omega-3 related supplements * consume omega-3 fatty acid rich fish (tuna, salmon, etc.) greater than two times per month -have any other diet-related conditions that would prevent them from consuming whey protein supplements and/or omega-3 fatty acid supplements * smoking * habitual alcohol consumption (\> 4 drinks/week) * medication impacting appetite or metabolism * Lipid or blood pressure lowering medication * Hormone replacement therapy

Locations (1)

University of Arkansas

Fayetteville, Arkansas, United States

Outcomes

Primary Outcomes

Sleep Quality

Pittsburgh Sleep Quality Index (PSQI) will assess sleep quality and disturbance. This is a elf-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. Nineteen individual items generate seven "component" scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The sum of scores for these seven components yields one global score. Each item is weighted on a 0-3 interval scale. The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality.

Time frame: Change in sleep quality from baseline (day 0) to 16 weeks.

Secondary Outcomes

Dietary intake

Dietary intake will be measured using 3-day, weighed food records.

Time frame: Change in dietary intake from baseline (day 0) to 16 weeks.

Sleep Quantity

Sleep duration will be measured using Actigraph monitors worn on the wrist.

Time frame: Change in sleep quantity from baseline (day 0) to 16 weeks.

Body composition

Body composition will be measured using dual x-ray absorptiometry (DEXA).

Time frame: On day 1 and day 112 (final day of 16-week intervention) of study.

Resting energy expenditure (REE)

REE will be measured using indirect calorimetry.

Time frame: On day 1 and day 112 (final day of 16-week intervention) of study.

Orexin

Intravenous blood samples will be collected and orexin measured using a commercial kit.

Data from ClinicalTrials.gov

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