The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preeclampsia. The secondary objective of the study is to analyze the relationship between preeclampsia and periodontal infection, using clinical, biochemical and microbiological methods.
Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preeclampsia. It is believed that the results will set light to the etiology of preeclampsia and will help to develop strategies to prevent the disease.
Study Type
OBSERVATIONAL
Enrollment
100
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
Ege University Dentistry Faculty
Izmir, Turkey (Türkiye)
RECRUITINGİzmir Health Sciences University, Tepecik Training and Research Hospital Department of Obstetrics and Gynecology
Izmir, Turkey (Türkiye)
RECRUITINGRecep Tayyip Erdogan University Dentistry Faculty
Rize, Turkey (Türkiye)
prostaglandin E2
prostaglandin E2 levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml
Time frame: 1 Day
TNF-Alpha (Tumor necrosis factor -Alpha)
TNF-Alpha levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml
Time frame: 1 day
IL-1beta (Interleukin 1 beta)
IL-1beta levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml
Time frame: 1 day
Porphyromonas gingivalis
Presence of Porphyromonas gingivalis will be checked by rPCR method. Score 1: Present Score 2: None Tannerella Forsythia (+,-)
Time frame: 1 Day
Tannerella Forsythia
Presence of Tannerella Forsythia will be checked by rPCR method. Score:1 Present. Score 2: None
Time frame: 1 Day
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Recep Tayyip Erdogan University Faculty of Medicine
Rize, Turkey (Türkiye)
ACTIVE_NOT_RECRUITINGGlaskow Dental School , School of Medicine University of Glasgow
Glaskow, United Kingdom
ACTIVE_NOT_RECRUITING