Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

Patient Eligibility Criteria Inclusion Criteria: * Age and CVD characteristics * Primary prevention: * 50-70 years of age * Self-report clinical characteristics that result to 20% or higher, 10-year risk of CVD based on the Progetto Cuore scores * Secondary prevention: * 18 years or older * Having a self-reported history of CV event (e.g., myocardial infarction (MI), ischaemic stroke or Transient Ischaemic stroke, , and angina) * Able to read and understand Italian * No participation in an investigational program with interventions outside of routine clinical practice * For qualitative interviews: * Willing and able to provide (electronic) informed consent to participate in the study * Willing and able to participate in a telephone interview, and to be audio-recorded * For pilot/cognitive interviews : * Willing and able to complete an online survey * Willing and able to provide (electronic) informed consent to participate in the study * Willing and able to participate in an in-person interview, and to be audio-recorded * For quantitative main survey: * Willing and able to complete an online survey * Willing and able to provide (electronic) informed consent to participate in the study Exclusion Criteria: * Have glucose-6-phosphate dehydrogenase (G6PD) deficiency (which commonly causes haemolytic anaemia, which is often triggered from eating fava beans, a condition called Favism) * Have the following conditions (which are contraindications to low-dose aspirin) * Known hypersensitivity to salicylates * Known to have had asthma induced by salicylates * Having been diagnosed with acute gastroduodenal ulcers * Haemorrhagic diathesis * Renal failure * Hepatic failure * Concomitant treatment with methotrexate * Cognitive impairment, hearing difficulty, visual impairment, acute psychopathology, or insufficient knowledge of Italian that-in the opinion of the investigator/interviewer-could interfere with a patient's ability to provide written consent and complete an interview or survey * To be currently pregnant * Are pharmaceutical company employees or employed in a position where they have a direct role in treating patients with CVD Physician Eligibility Criteria: * A medically trained physician * Able to read, speak, and understand Italian sufficiently to complete an interview * Able to provide informed consent electronically * Have at least five year experience prescribing low-dose aspirin for primary and secondary prevention of CVD * Willing to be audio-recorded, including adherence to the interview instructions