To observe the efficacy and safety of simplified therapy regimen for treating with HIV-1 infected patients in Chinese real word.
This is an phase IV open-label, multicenter, single-arm clinical trial in. A total of 600 cases were planned to be recruited. These cases were given simplified therapy regimen of lopinavir (200mg) and ritonavir (50mg) (500mg, oral, bid ) combined with lamivudine (300mg, oral, qd. The observation duration is thirty-sixth months. Patients will be followed up before and 12, 24 and 36 months after receiving the simplified regimen, observing the viral inhibition rate and the change of CD4 cell count, the safety and patients'compliance.
Study Type
OBSERVATIONAL
Enrollment
600
It is a simplified therapy regimen study of lopinavir and ritonavir combined with lamivudine for HIV-1 infected patients in the real world of China.
Guangzhou 8th People's Hospital
Guangzhou, Guangdong, China
RECRUITINGThe rate of virus inhibition
the ratio of HIV RNA\< 50 copies/mL at 12, 24 or 36 months after treatment.
Time frame: 36 Months
The immunological ability
the count of CD4 cells
Time frame: 36 Months
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