Isolated nocturnal hypertension (INH) has been studied among the general population and hypertensive patients. However, little insight is available on the prognostic effect of INH in patients with chronic kidney disease (CKD). This study investigated the prognostic effect of INH in a cohort of Chinese patients with nondialysis CKD.
Patients with or without isolated nocturnal hypertension will be enrolled in this study, and the patients with isolated nocturnal hypertension will be randomly divided into two groups and treated with bedtime or awakening doses of potassium losartan. Any patients who had any antihypertension medication at bedtime would withdrawal the drugs for 2 weeks before ABPM. Patients with isolated nocturnal hypertension will be randomly divided into two groups and received a bedtime or awakening dose of potassium losartan.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
252
treated with bedtime or awakening doses of potassium losartan
renal events and Cardiovascular events
doubled creatine or renal replacement, myocardial infarction, heart failure, stroke, vascular reconstruction, peripheral vascular disease, non-traumatic amputation
Time frame: 5 years
proteinuria
24h proteinuria \>1g
Time frame: 5 years
renal function
eGFR\<30ml/min/1.73m2
Time frame: 5 years
Thickness of the medial membrane of the carotid artery
cIMT \>1mm
Time frame: 5 years
Left ventricle weight index
LVMI \>115g/m2 (man) 和 \>95g/m2 (woman)
Time frame: 5 years
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