Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

National Cheng-Kung University Hospital131 enrolled

Overview

Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.

The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.

Study Type

OBSERVATIONAL

Enrollment

131

Conditions

Pain

Interventions

pain evaluationBEHAVIORAL

collect CSF during spinal anesthesia

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * . Patients undergo spinal anesthesia * . Over 20 years of age * Patients who are competent to understand the study and provide written informed consent. Exclusion Criteria: * Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis) * Refuse participated in this study or pre-existent neurological disease. * Patients with advanced tumor staging (stage 3 or 4).

Locations (1)

National Cheng Kung University

Tainan, Taiwan

Outcomes

Primary Outcomes

cytokine measurement in cerebrospinal fluid

cytokine measurement ( via ELISA) in cerebrospinal fluid

Time frame: through study completion, an average of 1 year

cytokine measurement in blood

cytokine measurement (via ELISA) in blood

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

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