mFLOT Chemotherapy as First-line Treatment in GC

Inclusion Criteria: 1. Male/female patients aged from 18 to 75 years. 2. Histologically confirmed gastric adenocarcinoma. 3. Gastric tumors should be treatment naïve unresectable or metastatic disease, or recurrence over 6 months after finish of adjuvant chemotherapy. 4. At least one measurable lesion should be confirmed by imaging examination. 5. ECOG performance status 0 or 1 6. Adequate bone marrow function: Absolute neutrophil count (ANC) ≥1.5x109/L White blood count ≥3.5x109/L Platelets ≥80x109/L Hemoglobin (Hb) ≥90g/L (can be post-transfusion) 7. Adequate renal function: Creatinine Clearance of \>50ml/min 8. Adequate liver function: Serum bilirubin \<22 umol/L ALT/AST ≤2.5x ULN, for patient with liver metastasis ALT/AST ≤5x ULN 10. Adequate coagulation profile International Normalised Ratio (INR) \< 1.5 Activated Prothrombin Time (APTT) \< 1.5xULN 11. Without brain metastasis and peripheral nerve diseases 12. Willingness and ability to comply with the protocol for the duration of the study including scheduled visits, examinations, investigations and treatment plans with informed consent form. Exclusion Criteria: 1. With second primary malignant diseases 2. Any contraindication or known hypersensitivity reaction to any of the study drugs, or components of leucovorin, oxaliplatin, 5-FU or docetaxel 3. With uncontrollable complications 4. Inadequate organ function 5. Pregnancy or of child bearing potential.