The study will try to access the efficacy of atrial pacing, medication and radiofrequency ablation in treating patients with paroxysmal atrial fibrillation and sinus node dysfunction; to identify the response to these treatments in patients with "functional" and organic sinus node dysfunction respectively; to explore the necessity of pacemaker implantation in patients with "functional" sinus node dysfunction. Patients who meet the inclusion criteria will receive pacemaker implantation followed by trial pacing, medication and radiofrequency ablation of AF. Device data will be analyzed to answer the question. And after follow-up of 1 year, lower rate of pacemaker will be set as 40 bpm for patients without AF. The proportion of pacing and patients' tolerance will be analyzed.
Study Type
OBSERVATIONAL
Enrollment
200
Different programing parameters will be set in different group/stage
AF ablation can only be performed in Step 3
Anti arryhthmic drugs can be prescribed in Step 2, Step3 and SAFE PAF-SND
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
proportion of ventricular pacing
Time frame: through study completion, an average of 2 years
symptom related to bradycardia
Time frame: through study completion, an average of 2 years
AF burden
Time frame: through study completion, an average of 2 years
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