Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels

Antalya Training and Research Hospital66 enrolled

Overview

The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.

Patients undergoing radical prostatectomy are at increased risk of acute kidney injury (AKI) because of intraoperative bleeding, obstructive uropathy and older age. In particular robot-assisted laparoscopic radical prostatectomy (RALP) which is in increasing demand as an alternative surgical option for retropubic radical prostatectomy (RRP) is associated with postoperative renal dysfunction because pneumoperitoneum during RALP can decrease cardiac output and renal perfusion. NGAL may become important for diagnosis of postoperative AKI after urogenital oncosurgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Prostatectomy

Interventions

NGALPROCEDURE

Eligibility

Sex: MALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who undergo prostatectomy * American Society of Anesthesiology (ASA) I-III Exclusion Criteria: * preexisting renal disease * emergency surgery * heart failure * peripheral vascular disease

Locations (1)

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Plasma NGAL

Plasma NGAL was determined at baseline, 6 hours and 12 hours after surgery, ng/ml

Time frame: 0 hours, 6 hours and 12 hours after surgery

Data from ClinicalTrials.gov

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